Selected publications (Dirk Isbrandt)

Control of heart rate by cAMP sensitivity of HCN channels.
Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94.
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C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.
Hum Mol Genet. 2006 Oct 1;15(19):2888-902.
Free article at journal site

Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.
Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D.
Nat Neurosci. 2005 Jan;8(1):51-60.
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Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency.
Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschütz R, Heerschap A, De Deyn PP, Neubauer S, Isbrandt D.
Hum Mol Genet. 2004 May 1;13(9):905-21.
Free article at journal site

Pacemaker channel dysfunction in a patient with sinus node disease.
Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D.
J Clin Invest. 2003 May;111(10):1537-45.
Free article in PMC | at journal site

Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.
Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D.
Neurobiol Dis. 2002 Nov;11(2):298-307.
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Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.
Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D.
J Biol Chem. 2001 Jun 29;276(26):23888-94.
Free article at journal site